Biochemical and molecular studies of human methenyltetrahydrofolate synthetase.

نویسندگان

  • J Jolivet
  • A Dayan
  • M Beauchemin
  • D Chahla
  • A Mamo
  • R Bertrand
چکیده

5-FormylH4folate is administered clinically under the name Leucovorin in association with the antineoplastic agent 5-fluorouracil (5-FU) to enhance the cytotoxic effects of 5-FU. The combination has been shown to be superior to 5-FU alone in the treatment of patients with metastatic colorectal carcinoma. Methenyltetrahydrofolate synthetase (MTHFS) catalyzes the transformation of 5-formyl-tetrahydrofolate to methenylH4folate, which is the obligatory initial metabolic step prior to the intracellular conversion of 5-formylH4folate to other reduced folates and the increase in intracellular folate pools required for 5-FU potentiation. In the following paper, we will summarize results of biochemical and molecular studies of human MTHFS.

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عنوان ژورنال:
  • Stem cells

دوره 14 1  شماره 

صفحات  -

تاریخ انتشار 1996